Police have revealed the haul was found as the result of a warrant being executed in the Fishtoft Road area of the town.
Police say the cannabis plants, which were housed in a 50,000 square foot unit, is the largest scale ever seen in Lincolnshire.
Police executed the warrant last Friday (March 26) and say the operation required the ‘tireless efforts of a large number of staff’.
Three men, aged 20, 23 and 25 have been charged and remanded into custody.
A spokesperson for the force said cannabis grows of this size are often linked with serious and organised crime and other criminality.
T/Detective Inspector Mark Seage said: “This was a huge challenge. It required the dedicated efforts of staff from a number of policing departments.
“I would like to say a massive thank you to everyone involved. We take such investigations very seriously and every member of staff worked incredibly hard.
“We work very closely with partners, taking a robust and proactive stance in order to reduce the risk to communities through rigorous investigations.
“Cannabis cultivation happens in both commercial and residential premises. We urge landlords to be stringent and vigilant in the letting of their properties and if they have any suspicions or concerns, to come to us and report them.
“Communities can also play a role in passing on any information they have about drugs in our county. The policing activity will have been noticed locally and we appreciate the support, patience and cooperation from residents.”
Anyone who has information or suspicions concerning illegal drugs cultivation can call us on 101 or contact the independent charity Crimestoppers on 0800 555 111.