The single-vehicle collision happened on the B1397 Old Spalding Road, Wigtoft.
A man in his 20s was seriously injured and taken to hospital, say police.
Police are unclear when the accident took place, but they arrived on the scene at just after 11pm.
The crash is believed to have happened sometime between 9pm and the arrival of emergency services on the team.
The man, who was driving a blue Hyundai iX35, was staken to hospital.
Police say thewy would like to speak to anyone who may have witnessed the collision or anyone who may have captured dashcam footage of the incident.
They ask anyone who can help to call 101 quoting incident 489 of March 6 2021, email [email protected] with 'incident 489 of March 6 2021' in the subject line, or anonymously, via the independent charity, CrimeStoppers on 0800 555 111 or online