Their On The Road Again Tour 2015 will bring Louis back home to South Yorkshire on Thursday and Friday, October 29 and 30.
The nights will also mark the end of their 18 date UK and Ireland tour.
Tickets - which will be priced £71.50, £52.25 & £43.45, including fees - go on sale on Saturday, December 6, 9am.
At the promoters request no tickets for this tour will be on sale in person from the venue.
The Arena will only be selling its allocation of tickets for this event online at www.motorpointarenasheffield.co.uk or through the ticket hotline on 0114 256 5656.
The brand new tour follows already announced dates in Europe, North America, Asia and South Africa.
It will give fans the chance, for the first time, to see the band perform songs from their brand new album, FOUR, alongside all their much-loved hits.
After a one-off performance in Cardiff’s Millennium Stadium in June 2015, the boys’ full tour kicks off at London’s The O2 in September and wraps up a month later with the two shows in Sheffield.
FOUR is their biggest yet, having topped the number one spot on the iTunes chart in 85 countries, with sales of over 2 million in just one week.
The album has also seen them make history by becoming the first ever act to debut at the top of the US Billboard charts with each of their first four albums.
For more about the tour, visit the official web site at www.ontheroadagain1d.com.
The full UK & Ireland tour dates are:
Saturday 6th June – Millennium Stadium, Cardiff
Thursday 24th September – The O2, London
Friday 25th September – The O2, London
Saturday 26th September – The O2, London
Saturday 3rd October – Arena, Manchester
Sunday 4th October – Arena, Manchester
Wednesday 7th October – The SSE Hydro Arena, Glasgow
Thursday 8th October – The SSE Hydro Arena, Glasgow
Saturday 10th October – Barclaycard Arena, Birmingham
Sunday 11th October – Barclaycard Arena, Birmingham
Friday 16th October – 3Arena, Dublin
Saturday 17th October – 3Arena, Dublin
Tuesday 20th October – Odyssey Arena, Belfast
Wednesday 21st October – Odyssey Arena, Belfast
Sunday 25th October – Metro Radio Arena, Newcastle
Monday 26th October – Metro Radio Arena, Newcastle
Thursday 29th October – Motorpoint Arena, Sheffield
Friday 30th October – Motorpoint Arena, Sheffield
All tickets go on sale Saturday 6th December at 9am.