Lincolnshire Police were called to reports of a road traffic collision at the B1190 Doddington Road, near to the Tom Otter's Lane and A57 junction near Saxilby just after 3.30pm.
Despite the best efforts of medical staff, one man was pronounced dead at the scene.
A woman and child travelling in a different vehicle were taken to hospital to be treated for their injuries, which are not believed to be life-threatening at this time.
The road was closed at 3.30pm and remained closed until around 2am this morning to allow officers to carry out initial investigations and recover the vehicles.
The police are appealing for anyone who was in the area and may have witnessed the crash to contact them.
You can contact the police by emailing [email protected], call 101, quoting incident 293 of July 8, or call Crimestoppers anonymously on 0800 555 111.