Marsh Road, Marsh Lane on East Side Marsh and Burgh Road was closed just before 1:30pm and has remained closed for some time.
The female driver of the Focus was sadly pronounced dead at the scene. Her next of kin have been informed and are being supported by specially-trained officers.
The male and female passenger of the Focus were also taken to hospital after sustaining serious injuries.
The driver and passenger of the van sustained injuries, which are not believed to be serious, and were also taken to hospital.
Police appealing for witnesses and anyone who may have captured dashcam footage of the collision to get in touch by calling 101, quoting incident 191 of 19th May.
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