Agnew and Henry to make Boston United starts against FC United of Manchester
Midfielder Agnew, 21, agreed to join the Pilgrims this week after a previously successful loan spell from Sunderland in the 2013-14 season.
Teenage keeper Henry, meanwhile, has linked up on loan from Peterborough United until January 1.
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Hide AdThe 18-year-old has been thrown into the starting XI at the expense of Christian Dibble, who is not in the matchday squad.
Agnew will take his place in central midfield alongside Herve Pepe-Ngoma.
The hosts still have a string of injury probles, with Nat Brown, Callum Chippendale, Grant Roberts, Kalern Thomas and Shane Clarke sidelined.
Boston are going in search of their second win of the National League North campaign, picking up just four points from their seven opening matches.
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Hide AdHowever, their last two home matches have picked up those points, a 1-1 draw with Kidderminster Harriers and a 3-0 success against Tamworth.
The Pilgrims have enjoyed a good rate of return against the Rebels.
From their previous seven meetings, Boston have won six and lost just once.
Kick off will be at 3pm.
Follow @standardduncan on Twitter for updates or log onto www.bostonstandard.co.uk for a match report at full time.