Northgate Olympic made their Workforce Unlimited Premier Division debut - but found Skegness Town too strong for them as the seasiders won the game 4-0.
Railway Athletic made a winning start against Swineshead Institute, succeeding 6-3.
Old Leake and Fulbeck United shared the points 3-3, Will Gosling, Ashley Jackson and Tom Ruck hitting the goals for Old Leake.
Spilsby Town had a fine away win at Pointon with a 5-1 victory and Wyberton Reserves got three points as they beat Coningsby 2-1.
Kirton Town got off to a winning start in division one as they beat Park United 3-2, Liam Ogden hitting both goals for Park.
Boston Town Reserves beat Pointon Reserves 3-0, Shane Brackenbury (two) and Carl Tate on target.
Railway Athletic Reserves beat Horncastle Town 2-1 and Black Bull and Woodhall Spa shared the points in a 4-4 score line.
In Division Two Fishtoft and Billinghay Athletic drew 3-3, Leon Creasey (two) and one from Damien Gibbons earned Fishtoft a point.
Spilsby Town Reserves and Woodhall Spa Reserves played out a 2-2 scoreline while Swineshead Institute Reserves beat Coningsby Reserves 4-2 - Dean Seiner, Luke Hackett (two) and Tony Webbthe matchwinners.
Division Three newcomers Boston Bears didn't get off to the start they would have liked as they were beaten 4-1 by Boston College Reserves.
Pinchbeck United Sports got off to a winning start as they beat Eagle United Reserves 3-1 and Park United Reserves beat Swineshead Institute A 5-0, Tom Limb hitting a fine hat trick with Kieran Handson and Junior Samra scoring one piece.
In the Target Challenge Cup's fist round Wyberton A came from 5-0 down to finally beat Sibsey 6-5 after extra time.
Ben Calaghan hit the winning goal.
Eagle United entertained FC Hammers for the second week in a row and, again, they came out on top with a 4-0 win.
FC Wrangle eased through to the next round with a 5-1 victory against Boston Athletic while Boston College were made to work hard for their 3-0 victory as they entertained Skegness Town A.
Holbeach Bank came out on top as they beat Caythorpe 4-3.
Mareham and Freiston shared a nine-goal thriller with Mareham finally winning the game 5-4.