Hosting Tetney Rovers in Division One, the Louth side were stunned by five goals in the first half and went on to lose 6-0.
Louth Town Reserves were 3-0 behind at the break of their Town Trophy quarter-final at Immingham Town Reserves.
But goals from Robin Beecroft and sub Tom Austwick put them back in the two-legged tie.
They will need to overturn a 4-2 deficit in the second leg on January 25.
Jess Marshall’s hat-trick took Alford Town back to the top of Division Two with a 4-1 win at Louth Old Boys Reds, Sam Allen with the other goal.
Sutton Rovers take a lead into the second leg of their Town Trophy quarter-final after beating GB Kitchens 4-2 at home.
And in Division Two, Louth Old Boys Vets lost 6-2 at title-chasing Burgh Athletic despite goals from Michael Goy and Andy Smith.