The White Wolves climbed up to fourth the previous weekend after a find run of six wins in seven league matches.
And they continued their momentum as Town held a slender 1-0 lead at half-time and carried it deep into the second half.
But Sean Cann levelled midway through the half, and Lewis Smith put the hosts ahead five minutes later.
Smith wrapped up a 3-1 win two minutes from time.
Louth drop to fifth, leapfrogged by Horncastle Town, and head to eighth-placed Wyberton on Saturday for a 2pm kick-off.